ORC1

origin recognition complex, subunit 1

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

ORC1 (3)

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No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

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Human (2)

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293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human ORC1 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G64643

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

25 µg/$670; 10 µg/$479

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Human ORC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77829

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.2 kDa

Price:

20 µg/$150

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ORC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116838

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.2 kDa

Price:

100 µg/$494

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