ORC1

origin recognition complex, subunit 1

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Products

Antibodies (15)

Type

Primary (15)

Target

ORC1 (15)

Reactivity

Human (15)

Mouse (5)

Rat (4)

Hamster (1)

Application

IHC (1)

WB (13)

ELISA (5)

IF (1)

IP (2)

Peptide-ELISA (2)

Host

rabbit (12)

mouse (1)

rat (2)

Isotype

IgG (9)

IgG1 (2)

IgG2b,k (1)

Clonality

monoclonal mc (3)

polyclonal pc (12)

Clone

3H1 (1)

7A7 (1)

Format

Unconjugated (15)

Epitope

aa170-220 (2)

300-380 aa, Internal (1)

Internal (1)

aa305-354 (1)

aa364-409 (1)

aa811-861 (1)

Publications

No (15)

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ORC1 Antibody LS-C804709

Antibody:

ORC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ORC1 Antibody LS-C832045

Antibody:

ORC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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ORC1 Antibody LS-C742620

Antibody:

ORC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ORC1 Antibody LS-C823645

Antibody:

ORC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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ORC1 Antibody (300-380 aa, Internal) LS-C385236

Antibody:

ORC1 Rabbit anti-Human Polyclonal (300-380 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ORC1 Antibody (clone 7A7) LS-C82308

Antibody:

ORC1 Rat anti-Human Monoclonal (7A7) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

0.05 mg/$429

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ORC1 Antibody (aa811-861) LS-C286088

Antibody:

ORC1 Rabbit anti-Human Polyclonal (aa811-861) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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ORC1 Antibody (aa305-354) LS-C200439

Antibody:

ORC1 Rabbit anti-Human Polyclonal (aa305-354) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ORC1 Antibody (clone 3H1) LS-C133921

Antibody:

ORC1 Mouse anti-Human Monoclonal (3H1) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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ORC1 Antibody LS-C37896

Antibody:

ORC1 Rat anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Hamster, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$665

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ORC1 Antibody (aa170-220) LS-C144088

Antibody:

ORC1 Rabbit anti-Human Polyclonal (aa170-220) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$583

Select

ORC1 Antibody (aa364-409) LS-C313867

Antibody:

ORC1 Rabbit anti-Human Polyclonal (aa364-409) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

ORC1 Antibody (aa170-220) LS-C148626

Antibody:

ORC1 Rabbit anti-Human Polyclonal (aa170-220) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$386

Select

ORC1 Antibody (Internal) LS-C352607

Antibody:

ORC1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

ORC1 Antibody LS-C749741

Antibody:

ORC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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