OPTN / Optineurin

optineurin

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

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Products

Proteins (20)

Type

Over-Expression Lysate (12)

Recombinant (8)

Target

OPTN / Optineurin (20)

Publications

No (20)

Tag

6His, N-terminus (2)

9His, C-terminus (1)

GST (2)

His (1)

His-T7 (1)

Myc-DDK (Flag) (13)

Species

Human (13)

Mouse (1)

Source

293T Cells (6)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (5)

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Human OPTN / Optineurin Protein (Recombinant 6His, N-terminus) (aa1-577) - LS-G57236

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121892

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$494

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OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121893

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$710

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OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121896

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$710

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OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123565

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$494

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OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123566

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$494

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Human OPTN / Optineurin Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G137079

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

69.9 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human OPTN / Optineurin Protein (Recombinant GST) (Full Length) - LS-G31969

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

88.55 kDa

Price:

10 µg/$479; 25 µg/$670

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Human OPTN / Optineurin Protein (Recombinant GST) (Full Length) - LS-G31970

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.21 kDa

Price:

10 µg/$479; 25 µg/$670

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Human OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87463

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$215

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Human OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87465

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$150

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Human OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87466

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$150

Select

Human OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87460

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$150

Select

Human OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87462

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$150

Select

Human OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87461

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$215

Select

OPTN / Optineurin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110511

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$494

Select

Mouse OPTN / Optineurin Protein (Recombinant His) (aa1-300) - LS-G25042

Source:

E. coli

Tag:

His

Molecular Weight:

38.0 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human OPTN / Optineurin Protein (Recombinant His-T7) (aa2-200) - LS-G25484

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human OPTN / Optineurin Protein (Recombinant 9His, C-terminus) (aa1-577) - LS-G57419

Source:

Baculovirus

Tag:

9His, C-terminus

Price:

100 µg/$1,067; 20 µg/$447; 1 mg/$1,988

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Human OPTN / Optineurin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70566

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$1,107

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