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OPRS1 / SIGMAR1
sigma non-opioid intracellular receptor 1
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
| Gene Name: | sigma non-opioid intracellular receptor 1 |
| Synonyms: | SIGMAR1, HSigmaR1, ALS16, SIG-1R, Sigma 1-type opioid receptor, SR-BP, Opioid receptor, sigma 1, OPRS1, Sigma1-receptor, SR31747-binding protein, SRBP, Sigma1R, SR-BP1, SR31747 binding protein 1 |
| Target Sequences: | NM_005866 NP_005857.1 Q99720 |
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