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OPRL1 / ORL1

opiate receptor-like 1

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Gene Name: opiate receptor-like 1
Family/Subfamily: GPCR , Opioid
Synonyms: OPRL1, Kappa-type 3 opioid receptor, KOR-3, Kor3, N/OFQ receptor, Nop receptor, Opioid receptor-like protein, Opiate receptor-like 1, Orphanin FQ receptor, Kappa3-related opioid receptor, Xor1, Nociceptin receptor, NOCIR, OOR, Opioid receptor-like 1, ORL1, Ror-c
Target Sequences: NM_000913 NP_000904.1 P41146

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
OPRL1 / ORL1 (6)
No (6)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
OPRL1 / ORL1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
OPRL1 / ORL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.5 kDa
20 µg/$150
OPRL1 / ORL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.5 kDa
20 µg/$150
OPRL1 / ORL1 Protein - 12.5% SDS-PAGE of human OPRL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
67.1 kDa
2 µg/$439
OPRL1 / ORL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.5 kDa
100 µg/$494
OPRL1 / ORL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
40.5 kDa
100 µg/$494
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).