OPRK1 / Kappa Opioid Receptor

opioid receptor, kappa 1

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

OPRK1 / Kappa Opioid Receptor (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human OPRK1 / Kappa Opioid Receptor Protein (Recombinant GST, N-terminus) (aa1-58) - LS-G59475

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human OPRK1 / Kappa Opioid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76974

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.5 kDa

Price:

20 µg/$150

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OPRK1 / Kappa Opioid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99216

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.5 kDa

Price:

100 µg/$494

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