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OPG / Osteoprotegerin
tumor necrosis factor receptor superfamily, member 11b
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
| Gene Name: | tumor necrosis factor receptor superfamily, member 11b |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF11B, OCIF, OPG, Osteoprotegerin, TR1 |
| Target Sequences: | NM_002546 NP_002537.3 O00300 |
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