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OPA1

optic atrophy 1 (autosomal dominant)

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.

Gene Name: optic atrophy 1 (autosomal dominant)
Synonyms: OPA1, KIAA0567, MGM1, LargeG, NPG, NTG, Optic atrophy protein 1
Target Sequences: AB011139 BAA25493.1 O60313

Publications (6)

1
High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse) [PubMed:21641551] [PMC:PMC3293110]
2
Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. Dai DF, Hsieh EJ, Liu Y, Chen T, Beyer RP, Chin MT, MacCoss MJ, Rabinovitch PS. Cardiovascular research. 2012 93:79-88. (WB; Mouse) [PubMed:22012956] [PMC:PMC3243039]
3
Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. Vallon M, Aubele P, Janssen KP, Essler M. The Biochemical journal. 2012 441:937-44. [PubMed:22013897]
4
Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation. Johnson D, Allman E, Nehrke K. American journal of physiology. Cell physiology. 2012 302:C1045-54. (WB; Rat) [PubMed:22237403] [PMC:PMC3330737]
5
Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, Siddiqui A, Tamura Y, Sesaki H, Wengenack TM, Dzeja PP, Poduslo JF. PloS one. 2012 7:e32737. (WB; Mouse) [PubMed:22393443] [PMC:PMC3290628]
6
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import. Brian C Lin, Trong H Phung, Nicole R Higgins, Jessie E Greenslade, Miguel A Prado, Daniel Finley, Mariusz Karbowski, Brian M Polster, Mervyn J Monteiro. Human molecular genetics. 2021 June;30:1230-1246. [Full Text Article] [PubMed:33891006] [PMC:PMC8212775] Related Antibodies: LS-C143234.
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☰ Filters
Antibodies (19)
Proteins (15)
ELISA Kits (2)
Over-Expression Lysate (12)
Primary (19)
Recombinant (3)
Sandwich (2)
OPA1 (36)
Human (20)
Mouse (18)
Rat (19)
Bovine (4)
Chicken (8)
Gibbon (3)
Guinea pig (3)
Hamster (2)
Horse (3)
Monkey (3)
Orangutan (3)
Pig (5)
Rabbit (3)
Zebrafish (2)
IHC (9)
IHC-P (9)
WB (19)
ELISA (1)
ICC (1)
IF (1)
Peptide-ELISA (2)
rabbit (18)
mouse (1)
Product Group
IHCPlus (2)
IgG (5)
monoclonal mc (1)
polyclonal pc (18)
1E8-1D9 (1)
96-Well Microplate (2)
Biotin Conjugated (2)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (12)
Internal (4)
aa151-200 (4)
C-Terminus (1)
aa500-600 (1)
aa895-929 (1)
aa901-950 (1)
aa919-955 (1)
No (35)
Yes (1)
Cell Lysates (2)
Tissue Homogenates (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (13)
Human (9)
293T Cells (6)
HEK 293 Cells (7)
Wheat Germ Extract (2)
Purified (1)
OPA1 Antibody - OPA1 Antibody (1E8-1D9) - IHC of OPA1 on mouse skin.
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OPA1 Mouse anti-Human Monoclonal (1E8-1D9) Antibody
Mouse, Bovine, Rat, Hamster, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
OPA1 Antibody - Anti-OPA1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (aa500-600) Antibody
Chicken, Rat, Pig, Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
OPA1 Antibody - Anti-OPA1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Chicken, Rat, Pig, Mouse, Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
OPA1 Antibody - Anti-OPA1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (Internal) (DY650) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
OPA1 Antibody - Anti-OPA1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (Internal) (DY488) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
OPA1 Antibody - Anti-OPA1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (Internal) (DY550) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
OPA1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$595
OPA1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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OPA1 Rabbit anti-Human Polyclonal (aa901-950) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
OPA1 Antibody - OPA1 antibody IHC-paraffin. IHC(P): Mouse Liver Tissue.
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OPA1 Rabbit anti-Human Polyclonal (aa919-955) Antibody
Mouse, Rat, Hamster, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
OPA1 Antibody - OPA1 antibody Western Blot of HT1080.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (aa151-200) Antibody
Human
WB
Unconjugated
100 µl/$424
OPA1 Antibody - OPA1 antibody Western Blot of HT1080.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (aa151-200) (HRP) Antibody
Chicken, Zebrafish, Pig, Horse, Bovine, Rabbit, Mouse, Guinea pig, Rat, Human, Monkey, Orangutan, Gibbon
WB
HRP Conjugated
100 µl/$469
OPA1 Antibody - OPA1 antibody Western Blot of HT1080.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (aa151-200) (Biotin) Antibody
Chicken, Zebrafish, Pig, Horse, Bovine, Rabbit, Mouse, Guinea pig, Rat, Human, Monkey, Orangutan, Gibbon
WB
Biotin Conjugated
100 µl/$469
OPA1 Antibody - OPA1 antibody Western Blot of HT1080.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OPA1 Rabbit anti-Human Polyclonal (aa151-200) (FITC) Antibody
Chicken, Bovine, Rat, Pig, Horse, Rabbit, Mouse, Guinea pig, Orangutan, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
OPA1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$646
OPA1 Antibody
Select
OPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
OPA1 Antibody - Western blot analysis OPA1 using COLO205 whole cells lysates
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OPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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OPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
OPA1 Antibody - Western blot of lysates from HeLa cell line , mouse brain and rat brain tissue lysate (from left to right) with OPA1 (form S1) Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.
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OPA1 Rabbit anti-Human Polyclonal (aa895-929) Antibody
Mouse, Rat, Human
WB
Unconjugated
400 µl/$393
OPA1 Antibody - Western blot analysis of extracts of various cell lines.
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OPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
OPA1 Antibody - Western blot of OPA1 antibody at 1:500 dilution. Lane 1: A549 whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: PC12 whole cell lysate.
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OPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
OPA1 Antibody - Western blot analysis of OPA1 expression in A549 (A); Raw264.7 (B); PC12 (C) whole cell lysates.
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OPA1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
OPA1 Protein - Purified recombinant protein OPA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
109.2 kDa
20 µg/$1,107
OPA1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
OPA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
111.5 kDa
20 µg/$150
OPA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
111.6 kDa
20 µg/$215
Viewing 1-25 of 36 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).