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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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OCLN / Occludin

occludin

OCLN / Occludin is an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.

Gene Name: occludin
Synonyms: OCLN, Occludin, BLCPMG
Target Sequences: NM_002538 NP_002529.1 Q16625

Publications (5)

1
The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation. Otsu K, Ida-Yonemochi H, Fujiwara N, Harada H. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 November;31:1943-1954. (Human) [Full Text Article] [PubMed:27218883] Related Antibodies: LS-B2320.
2
TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection. Kumar R, Gong H, Liu L, Ramos-Solis N, Seye CI, Derbigny WA. PloS one. 2019 January;14:e0207422. [Full Text Article] [PubMed:30625140] [PMC:PMC6326510] Related Antibodies: LS-B2187.
3
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H. PloS one. 2013 8:e75106. [Full Text Article] [PubMed:24116027] [PMC:PMC3792957] Related Antibodies: LS-B2187.
4
ATF3 Protects Pulmonary Resident Cells from Acute and Ventilator-Induced Lung Injury by Preventing Nrf2 Degradation. Shan Y, Akram A, Amatullah H, Zhou DY, Gali PL, Maron-Gutierrez T, Gonz[Character e1]lez-L[Character f3]pez A, Zhou L, Rocco PR, Hwang D, Albaiceta GM, Haitsma JJ, Dos Santos CC. Antioxidants & redox signaling. 2014 Mar;22:651-68. [Full Text Article] [PubMed:25401197] [PMC:PMC4346377] Related Antibodies: LS-B2187.
5
Protective role of uncoupling protein-2 against dextran sodium sulfate-induced colitis. Zhang H, Kuai XY, Yu P, Lin L, Shi R. Journal of gastroenterology and hepatology. 2012 Mar;27:603-8. [Full Text Article] [PubMed:21871020] Related Antibodies: LS-C50519.
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Viewing 1-25 of 69 items
OCLN / Occludin Antibody - Anti-Occludin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Neuroscience
(1) Publication(s)
Mouse Monoclonal [clone OC-3F10] (IgG1,k) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $485.00
OCLN / Occludin Antibody - Anti-Occludin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Neuroscience
(3) Publication(s)
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
ELISA, IF, IHC-P, IP, WB
Unconjugated
50µg   0.25mg/ml   $485.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Mammal, Human
ELISA, IF, IHC, IP, WB
HRP Conjugated
100µl   $800.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Mammal, Human
ELISA, IF, IHC, IP, WB
Biotin Conjugated
100µl   $800.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Mammal, Human
ELISA, IF, IHC, IP, WB
FITC Conjugated
100µl   $800.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Mammal, Human
ELISA, IF, IHC, IP, WB
AP Conjugated
100µl   $800.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Mammal, Human
ELISA, IF, IHC, IP, WB
PE Conjugated
100µl   $800.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Mammal, Human
ELISA, IF, IHC, IP, WB
APC Conjugated
100µl   $800.00
OCLN / Occludin Antibody - Anti-Occludin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Neuroscience
Rabbit Polyclonal to Human OCLN / Occludin
Zebrafish, Pig, Horse, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
OCLN / Occludin Antibody - Anti-Occludin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human OCLN / Occludin
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
OCLN / Occludin Antibody - Human Thryoid: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
Select
Guinea pig Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
IF, IHC, IHC-Fr, WB
Unconjugated
100µg   $475.00
Select
Mouse Monoclonal [clone OC-3F10] (IgG1,k) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
ELISA, IF, WB
FITC Conjugated
100µg   $710.00
OCLN / Occludin Antibody - Human Lung stained with Anti-Occludin
Select
(1) Publication(s)
Rabbit Polyclonal to Human OCLN / Occludin
Human
IHC, WB
Unconjugated
0.25ml   $530.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
OCLN / Occludin Antibody - Immunofluorescence of monoclonal antibody to OCLN on HeLa cell. [antibody concentration 10 ug/ml]
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Mouse Monoclonal [clone 1G7] (IgG1,k) to Human OCLN / Occludin
Human
ELISA, IF, IP, WB
Unconjugated
100µg   $365.00
OCLN / Occludin Antibody - IF using Occludin Antibody, Alexa Fluor® 488, Alexa Fluor® 488 conjugate (OC-3F10)
Select
Mouse Monoclonal [clone OC-3F10] (IgG1,k) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
ELISA, ICC, IF, WB
AF488 Conjugated
100µg   $405.00
Select
Rabbit Polyclonal to Mouse OCLN / Occludin
Mouse, Rat, Pig, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $325.00
Select
Mouse Monoclonal [clone OC-3F10] (IgG1,k) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
ELISA, IF, WB
HRP Conjugated
100µg   $635.00
OCLN / Occludin Antibody - Western blot of recombinant OCLN / Occludin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse OCLN / Occludin
Mouse
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $545.00
OCLN / Occludin Antibody - IF using Occludin Antibody, Alexa Fluor® 594, Alexa Fluor® 594 conjugate (OC-3F10)
Select
Mouse Monoclonal [clone OC-3F10] (IgG1,k) to Human OCLN / Occludin
Mouse, Dog, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
100µg   $445.00
OCLN / Occludin Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
OCLN / Occludin Antibody
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Mouse, Rat, Pig, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
OCLN / Occludin Antibody - Immunofluorescence staining of OCLN in Hek293 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-Human OCLN polyclonal antibody (dilution ratio 1:1500) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cell membrane and cytoplasm.
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Human
ICC, IF, WB
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Select
Rabbit Polyclonal (IgG) to Human OCLN / Occludin
Human
ELISA, IHC, WB
Unconjugated
100µg   $405.00

Viewing 1-25 of 69 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).