OAS3 / p100

2'-5'-oligoadenylate synthetase 3, 100kDa

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

OAS3 / p100 (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human OAS3 / p100 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89481

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

121 kDa

Price:

20 µg/$215

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OAS3 / p100 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115470

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

121 kDa

Price:

100 µg/$710

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