OAS1

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

OAS1 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Rat (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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OAS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112505

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.8 kDa

Price:

100 µg/$494

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OAS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117923

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.6 kDa

Price:

100 µg/$494

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Human OAS1 Protein (Recombinant GST) (Full Length) - LS-G29562

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat OAS1 Protein (Recombinant His-T7) (aa139-358) - LS-G25040

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human OAS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G73973

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.6 kDa

Price:

20 µg/$150

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Human OAS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G73975

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.8 kDa

Price:

20 µg/$150

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Human OAS1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64692

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.6 kDa

Price:

20 µg/$1,107

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Human OAS1 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59461

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human OAS1 Protein (Recombinant His) - LS-G596

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$511; 500 µg/$1,348; 20 µg/$311

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Human OAS1 Protein (Recombinant His) (aa74-165) - LS-G15023

Source:

E. coli

Tag:

His

Molecular Weight:

11.9 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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