OAS1

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

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Products

ELISA Kits (9)

Type

Custom (1)

Sandwich (8)

Target

OAS1 (9)

Reactivity

Human (3)

Mouse (2)

Rat (2)

Monkey (1)

Pig (1)

Format

96-Well Strip Plate (9)

Publications

No (9)

Sample Type

Plasma (8)

Serum (8)

Tissue Homogenates (3)

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Human OAS1 (Sandwich ELISA) ELISA Kit - LS-F12205

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human OAS1 (Sandwich ELISA) ELISA Kit - LS-F31934

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.469 - 30 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Mouse OAS1 (Sandwich ELISA) ELISA Kit - LS-F14317

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse OAS1 (Sandwich ELISA) ELISA Kit - LS-F6505

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pmol/l

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$854

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Pig OAS1 (Sandwich ELISA) ELISA Kit - LS-F14316

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human OAS1 (Sandwich ELISA) ELISA Kit - LS-F6594

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

4.7 - 300 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$834

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Rat OAS1 (Custom ELISA) ELISA Kit - LS-F14318

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Monkey OAS1 (Sandwich ELISA) ELISA Kit - LS-F32122

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat OAS1 (Sandwich ELISA) ELISA Kit - LS-F6190

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$893

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