NUPR1

nuclear protein, transcriptional regulator, 1

Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

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Products

Antibodies (11)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (11)

Recombinant (2)

Target

NUPR1 (15)

Reactivity

Human (11)

Chimpanzee (3)

Gibbon (3)

Monkey (4)

Application

IHC (1)

WB (6)

ELISA (4)

IF (1)

Peptide-ELISA (1)

Host

rabbit (10)

goat (1)

Isotype

IgG (6)

Clonality

polyclonal pc (11)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (5)

Epitope

C-Terminus (5)

N-Terminus (1)

aa2-14 (1)

Publications

No (15)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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NUPR1 Antibody LS-C500644

Antibody:

NUPR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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NUPR1 Antibody (HRP) LS-C500641

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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NUPR1 Antibody (Biotin) LS-C500645

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

NUPR1 Antibody (FITC) LS-C500642

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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NUPR1 Antibody (C-Terminus) LS-C151661

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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NUPR1 Antibody (C-Terminus, HRP) LS-C471851

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

NUPR1 Antibody (C-Terminus, Biotin) LS-C471849

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

NUPR1 Antibody (C-Terminus, FITC) LS-C471850

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

NUPR1 Antibody (C-Terminus) LS-C37961

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$444; 100 µg/$597

Select

NUPR1 Antibody (N-Terminus) LS-C37960

Antibody:

NUPR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$444; 100 µg/$597

Select

NUPR1 Antibody (aa2-14) LS-C55224

Antibody:

NUPR1 Goat anti-Human Polyclonal (aa2-14) Antibody

Reactivity:

Human, Monkey

Applications:

Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$401

Select

Human NUPR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87548

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.7 kDa

Price:

20 µg/$150

Select

Human NUPR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70603

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.7 kDa

Price:

20 µg/$1,107

Select

Human NUPR1 Protein (Recombinant GST) (Full Length) - LS-G33172

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

34.76 kDa

Price:

10 µg/$479; 25 µg/$670

Select

NUPR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114490

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.7 kDa

Price:

100 µg/$494

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