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NUDT5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
NUDT5 belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors.
| Gene Name: | nudix (nucleoside diphosphate linked moiety X)-type motif 5 |
| Synonyms: | NUDT5, 8-oxo-dGDP phosphatase, ADP-sugar pyrophosphatase, HYSAH1, Nudix hydrolase nudt5, YSA1, YSA1H, Nudix motif 5 |
| Target Sequences: | NM_014142 NP_054861.2 Q9UKK9 |
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