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NUDT21

nudix (nucleoside diphosphate linked moiety X)-type motif 21

Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.

Gene Name: nudix (nucleoside diphosphate linked moiety X)-type motif 21
Synonyms: NUDT21, CFIM25, CPSF25, CPSF 25 kDa subunit, CPSF5, Nudix motif 21
Target Sequences: NM_007006 NP_008937.1 O43809

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
NUDT21 (6)
No (6)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
NUDT21 Protein - Purified recombinant protein NUDT21 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
26 kDa
20 µg/$1,107
NUDT21 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
26 kDa
20 µg/$150
NUDT21 Protein - 12.5% SDS-PAGE of human CPSF5 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.71 kDa
10 µg/$479; 25 µg/$670
NUDT21 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26 kDa
100 µg/$494
NUDT21 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).