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Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear By similarity. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
Gene Name: | Nudix (nucleoside Diphosphate Linked Moiety X)-type Motif 15 |
Synonyms: | NUDT15, 8-oxo-dGTPase NUDT15, Nudix motif 15, RP11-90M2.1, MTH2, Nudix-type motif 15, MutT homolog 2 |
Target Sequences: | NM_018283 NP_060753.1 Q9NV35 |
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