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NUDT1 / MTH1

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene Name: nudix (nucleoside diphosphate linked moiety X)-type motif 1
Synonyms: NUDT1, 8-oxo-dGTPase, 2-hydroxy-dATP diphosphatase, MutT human homolog 1, Nudix motif 1, MTH1
Target Sequences: NM_002452 NP_002443.3 P36639

Publications (7)

1
Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Takeshita F, Ogawa K, Asamoto M, Shirai T. Cancer letters. 2003 194:25-35. (WB, IHC-P; Rat) [PubMed:12706856]
2
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue. Kennedy CH, Pass HI, Mitchell JB. Free radical biology & medicine. 2003 34:1447-57. (WB, IHC-Fr; Human) [PubMed:12757855]
3
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:169-74. [PubMed:19118192] [PMC:PMC2629241]
4
Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Rai P, Young JJ, Burton DG, Giribaldi MG, Onder TT, Weinberg RA. Oncogene. 2011 30:1489-96. [PubMed:21076467]
5
Acute responses of DNA repair proteins and StarD6 in rat hippocampus after domoic acid-induced excitotoxicity. Chang IY, Kim JH, Cho KW, Yoon SP. Acta histochemica. 2013 115:234-9. (WB; Mouse) [PubMed:22883302]
6
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K, Yamada H, Nakabeppu Y. The Journal of clinical investigation. 2012 122:4344-61. (ICC, IHC; Mouse) [PubMed:23143307] [PMC:PMC3533558]
7
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Pudelko L, Rouhi P, Sanjiv K, Gad H, Kalderén C, Höglund A, Squatrito M, Schuhmacher AJ, Edwards S, Hägerstrand D, Berglund UW, Helleday T, Bräutigam L. Oncotarget. 2017 July;8:84671-84684. (Human) [Full Text Article] [PubMed:29156675] [PMC:PMC5689565] Related Antibodies: LS-C197715.
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Antibodies (22)
Primary (22)
NUDT1 / MTH1 (22)
Human (22)
Mouse (7)
Rat (7)
IHC (13)
IHC-Fr (5)
IHC-P (6)
WB (16)
Flo (1)
ELISA (10)
ICC (5)
IF (3)
IP (7)
Peptide-ELISA (1)
rabbit (20)
mouse (2)
Product Group
IHCPlus (2)
IgG (10)
IgG1,k (1)
IgG2a,k (1)
monoclonal mc (2)
polyclonal pc (20)
5F11 (1)
AT3B3 (1)
Biotin Conjugated (2)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (15)
C-Terminus (5)
N-Terminus (1)
No (21)
Yes (1)
NUDT1 / MTH1 Antibody - Western Blot analysis of NUDT1 expression in transfected 293T cell line by NUDT1 monoclonal antibody (M02), clone 5F11.Lane 1: NUDT1 transfected lysate(18 KDa).Lane 2: Non-transfected lysate.
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NUDT1 / MTH1 Mouse anti-Human Monoclonal (5F11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
NUDT1 / MTH1 Antibody - Anti-NUDT1 / MTH1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
NUDT1 / MTH1 Antibody - Anti-NUDT1 / MTH1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P
Unconjugated
50 µl/$460
NUDT1 / MTH1 Antibody - Anti-NUDT1 / MTH1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, IP, WB
Biotin Conjugated
0.2 ml/$416
NUDT1 / MTH1 Antibody - Anti-NUDT1 / MTH1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, IP, WB
DY550 Conjugated
0.2 ml/$416
NUDT1 / MTH1 Antibody - Anti-NUDT1 / MTH1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, IP, WB
DY650 Conjugated
0.2 ml/$416
NUDT1 / MTH1 Antibody - Anti-NUDT1 / MTH1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, IP, WB
DY488 Conjugated
0.2 ml/$416
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
NUDT1 / MTH1 Antibody - ICC/IF analysis of NUDT1 in A549 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human NUDT1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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NUDT1 / MTH1 Mouse anti-Human Monoclonal (AT3B3) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
NUDT1 / MTH1 Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NUDT1 / MTH1 Antibody - Immunohistochemistry of paraffin-embedded human small intestine tissue using NUDT1 Antibody at dilution of 1:100
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
NUDT1 / MTH1 Antibody - Immunohistochemistry of paraffin-embedded human lung using NUDT1 antibody at dilution of 1:200 (200x lens).
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
NUDT1 / MTH1 Antibody - Immunohistochemistry of paraffin-embedded human gastric cancer using NUDT1 antibody at dilution of 1:100 (40x lens).
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
60 µl/$343; 120 µl/$427; 200 µl/$559
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$391; 100 µl/$489
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
NUDT1 / MTH1 Antibody - Western blot analysis of MTH1 expression in A549 (A); mouse liver (B); rat brain (C) whole cell lysates.
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NUDT1 / MTH1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
Viewing 1-22 of 22 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).