NUB1

negative regulator of ubiquitin-like proteins 1

NUB1 is a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.

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Products

Antibodies (31)

Proteins (5)

ELISA Kits (4)

Type

Cell-Based (1)

Custom (3)

Over-Expression Lysate (2)

Primary (31)

Recombinant (3)

Target

NUB1 (40)

Reactivity

Human (33)

Mouse (15)

Rat (2)

Bovine (1)

Dog (2)

Monkey (4)

Application

IHC (25)

IHC-P (7)

WB (30)

Flo (8)

ELISA (15)

IF (3)

IP (1)

Peptide-ELISA (2)

Host

rabbit (23)

mouse (8)

Isotype

IgG (18)

IgG1 (6)

IgG2a (2)

Clonality

monoclonal mc (8)

polyclonal pc (23)

Clone

OTI1B7 (2)

OTI1F3 (2)

OTI2G1 (2)

OTI4H2 (2)

Format

96-Well Microplate (1)

96-Well Strip Plate (3)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (2)

Carrier-free (4)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (21)

Epitope

aa513-542 (7)

aa87-117 (7)

aa1-326 (4)

540-620 aa, C-terminal (1)

C-Terminus (1)

Tyr601 (1)

aa566-615 (1)

Publications

No (40)

Sample Type

Adherent Cell Cultures (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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NUB1 Antibody (clone OTI4H2) LS-C175173

Antibody:

NUB1 Mouse anti-Human Monoclonal (OTI4H2) Antibody

Reactivity:

Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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NUB1 Antibody (aa1-326, clone OTI4H2, Carrier-free) LS-C788676

Antibody:

NUB1 Mouse anti-Human Monoclonal (aa1-326) (Carrier-free) (OTI4H2) Antibody

Reactivity:

Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

NUB1 Antibody (clone OTI2G1) LS-C175171

Antibody:

NUB1 Mouse anti-Human Monoclonal (OTI2G1) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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NUB1 Antibody (aa1-326, clone OTI2G1, Carrier-free) LS-C799463

Antibody:

NUB1 Mouse anti-Human Monoclonal (aa1-326) (Carrier-free) (OTI2G1) Antibody

Reactivity:

Human

Applications:

Flo, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

NUB1 Antibody LS-C800391

Antibody:

NUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NUB1 Antibody (aa87-117) LS-C98472

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

NUB1 Antibody (aa513-542) LS-C98473

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

NUB1 Antibody (aa513-542) LS-C328085

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

NUB1 Antibody (aa513-542, Biotin) LS-C280343

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

NUB1 Antibody (aa513-542, FITC) LS-C280344

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

NUB1 Antibody (aa513-542, APC) LS-C280341

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

NUB1 Antibody (aa513-542, Azide-free, HRP) LS-C280345

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

NUB1 Antibody (aa513-542, PE) LS-C280348

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa513-542) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

NUB1 Antibody (aa87-117) LS-C328086

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

NUB1 Antibody (aa87-117, Biotin) LS-C280349

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

NUB1 Antibody (aa87-117, FITC) LS-C280350

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

NUB1 Antibody (aa87-117, APC) LS-C280347

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

NUB1 Antibody (aa87-117, Azide-free, HRP) LS-C280352

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

NUB1 Antibody (aa87-117, PE) LS-C280351

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa87-117) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

NUB1 Antibody (540-620 aa, C-terminal) LS-C384981

Antibody:

NUB1 Rabbit anti-Human Polyclonal (540-620 aa, C-terminal) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

NUB1 Antibody LS-C821733

Antibody:

NUB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

NUB1 Antibody (aa566-615) LS-C118607

Antibody:

NUB1 Rabbit anti-Human Polyclonal (aa566-615) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

NUB1 Antibody (Tyr601) LS-C176340

Antibody:

NUB1 Rabbit anti-Human Polyclonal (Tyr601) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

NUB1 Antibody (C-Terminus) LS-C353452

Antibody:

NUB1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

NUB1 Antibody (clone OTI1F3) LS-C175172

Antibody:

NUB1 Mouse anti-Human Monoclonal (OTI1F3) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

100 µl/$434

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