Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
NTR1, a Neurotensin Receptor, activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems. It mediates the functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Neurotensin Receptor 1 expression is enhanced in pancreatic cancer and in chronic pancreatitis (Wang et al, 2000). Two differentially glycosylated forms of the NT1 receptor have been identified in rats, a 54-kD form that is expressed from birth to adulthood, and a 52-kD form only detected at 10 and 15 days postnatal.
|Gene Name:||neurotensin receptor 1 (high affinity)|
|Family/Subfamily:||GPCR , Neurotensin|
|Synonyms:||NTSR1, Neurotensin receptor type 1, NT-1r, NT1 receptor, NTR, NTS1, Neurotensin receptor 1, NT-R-1, NTR1, NTRH, NTRR, Neurotensin receptor ntr1, NTS-1, Neurotensin type 1 receptor, NT receptor-1, RNTR1|
|Target Sequences:||NM_002531 CAA49675.1 P30989|
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