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NTRK3 / TRKC

neurotrophic tyrosine kinase, receptor, type 3

NTRK3 / TRKC is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: neurotrophic tyrosine kinase, receptor, type 3
Family/Subfamily: Protein Kinase , Trk/Ror
Synonyms: NTRK3, ETV6-NTRK3 fusion, gp145-TrkC, Neurotrophin 3 receptor, TRKC, TrkC tyrosine kinase, NT-3 growth factor receptor, NT3 growth factor receptor, Tyrosine kinase receptor C, Pan Trk, gp145(trkC), Trk-C
Target Sequences: NM_002530 NP_002521.2 Q16288

Publications (1)

1
Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma. Seo E#, Kim JS#, Ma YE, Cho HW, Ju HY, Lee SH, Lee JW, Yoo KH, Sung KW, Koo HH. Journal of Korean Medical Science. 2019 October;34:e254. [Full Text Article] [PubMed:31602824] [PMC:PMC6786962]

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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
NTRK3 / TRKC (13)
No (13)
6His, C-terminus (1)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
GST, N-terminus (1)
His (2)
His,C-terminus (1)
His-Fc (1)
Myc-DDK (Flag) (5)
Human (10)
Mouse (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (7)
Human (1)
Human Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (4)
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HEK 293 Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
72.5 kDa
100 µg/$721
NTRK3 / TRKC Protein - Purified recombinant protein NTRK3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
89.3 kDa
20 µg/$1,107
NTRK3 / TRKC Protein - Purified recombinant protein NTRK3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
90.9 kDa
20 µg/$1,107
NTRK3 / TRKC Protein - Purified recombinant protein NTRK3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
64.9 kDa
20 µg/$1,107
NTRK3 / TRKC Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NTRK3 / TRKC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
92.8 kDa
20 µg/$215
NTRK3 / TRKC Protein - Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 By SDS-PAGE
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E. coli
His
48.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.1 kDa
100 µg/$721
NTRK3 / TRKC Protein - Recombinant Mouse TrkC/Ntrk3 (C-6His)
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Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.5 kDa
10 µg/$308; 50 µg/$502
NTRK3 / TRKC Protein
Select
Sf9 Cells
DDK,C-terminus
44.7 kDa
20 µg/$677
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
47 kDa
20 µg/$1,107
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
46.1 kDa
100 µg/$721
NTRK3 / TRKC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
92.8 kDa
100 µg/$710
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).