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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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NTRK3 / TRKC
neurotrophic tyrosine kinase, receptor, type 3
NTRK3 / TRKC is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | neurotrophic tyrosine kinase, receptor, type 3 |
| Family/Subfamily: | Protein Kinase , Trk/Ror |
| Synonyms: | NTRK3, ETV6-NTRK3 fusion, gp145-TrkC, Neurotrophin 3 receptor, TRKC, TrkC tyrosine kinase, NT-3 growth factor receptor, NT3 growth factor receptor, Tyrosine kinase receptor C, Pan Trk, gp145(trkC), Trk-C |
| Target Sequences: | NM_002530 NP_002521.2 Q16288 |
Publications (1)
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