NTRK2 / TRKB

neurotrophic tyrosine kinase, receptor, type 2

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

☰ Filters

Products

Proteins (22)

Type

Over-Expression Lysate (10)

Recombinant (12)

Target

NTRK2 / TRKB (22)

Publications

No (22)

Tag

6His, C-terminus (2)

Fc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His,C-terminus (2)

Myc-DDK (Flag) (12)

Species

Human (13)

Mouse (2)

Rat (2)

Source

293T Cells (5)

E. coli (1)

HEK 293 Cells (10)

Human (1)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (7)

Biologically Active

Biologically active (1)

Select

Human NTRK2 / TRKB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65048

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.1 kDa

Price:

20 µg/$1,107

Select

Human NTRK2 / TRKB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65050

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.3 kDa

Price:

20 µg/$1,107

Select

Human NTRK2 / TRKB Protein (Recombinant GST, N-terminus) (aa41-160) - LS-G59451

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74724

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.05 kDa

Price:

20 µg/$150

Select

Human NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74726

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92 kDa

Price:

20 µg/$215

Select

Human NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74728

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.99 kDa

Price:

20 µg/$215

Select

Human NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74730

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.17 kDa

Price:

20 µg/$215

Select

Human NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74731

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.83 kDa

Price:

20 µg/$215

Select

Human NTRK2 / TRKB Protein (Recombinant His) (aa32-430) - LS-G24669

Source:

E. coli

Tag:

His

Molecular Weight:

47.9 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Human NTRK2 / TRKB Protein (Recombinant GST) (Full Length) - LS-G29558

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.21 kDa

Price:

2 µg/$439

Select

Human NTRK2 / TRKB Protein (Recombinant 6His, C-terminus) (Cys32-His430) - LS-G39012

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.25kD

Price:

10 µg/$240; 50 µg/$299; 500 µg/$929; 1 mg/$1,245

Select

Human NTRK2 / TRKB Protein (Recombinant) - LS-G137758

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1 EU/µg (determined by LAL method).

Molecular Weight:

The 639 amino acid recombinant protein has a predicted molecular mass of approximately 71 kD. The protein migrates approximately at 125 kD in DTT-reducing conditions and at approximately 250 kD in a non-reducing conditions by SDS-PAGE. The predicted N-ter

Price:

10 µg/$283; 100 µg/$620

Select

Mouse NTRK2 / TRKB Protein (Recombinant 6His, C-terminus) - LS-G146274

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.3 kDa

Price:

10 µg/$373; 50 µg/$795

Select

NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115481

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.83 kDa

Price:

100 µg/$710

Select

Rat NTRK2 / TRKB Protein (Recombinant Fc, C-terminus) (Met1-His429) - LS-G140787

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.5 kDa

Price:

20 µg/$499

Select

Mouse NTRK2 / TRKB Protein (Recombinant His,C-terminus) (Met1-His429) - LS-G140783

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46 kDa

Price:

50 µg/$721

Select

Human NTRK2 / TRKB Protein (Recombinant His,C-terminus) (Cys32-His430) - LS-G138668

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.25 kDa

Price:

10 µg/$240; 50 µg/$299

Select

Rat NTRK2 / TRKB Protein (Recombinant His) (Met1-His429) - LS-G98449

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.1 kDa

Price:

20 µg/$443

Select

NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99276

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.05 kDa

Price:

100 µg/$494

Select

NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121251

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92 kDa

Price:

100 µg/$710

Select

NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121250

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.99 kDa

Price:

100 µg/$710

Select

NTRK2 / TRKB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121252

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.17 kDa

Price:

100 µg/$710

Viewing 1-22 of 22 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.