NTRK2 / TRKB

neurotrophic tyrosine kinase, receptor, type 2

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

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Products

ELISA Kits (26)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Sandwich (20)

Sandwich CLIA (3)

Target

NTRK2 / TRKB (26)

Reactivity

Human (8)

Mouse (10)

Rat (8)

Chicken (2)

Guinea pig (1)

Monkey (1)

Pig (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (9)

96-Well Strip Plate (13)

Publications

No (25)

Yes (1)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (5)

Cell Lysates (8)

Plasma (12)

Serum (12)

Tissue Homogenates (9)

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Mouse/Human/Rat NTRK2 / TRKB (Cell-Based ELISA) ELISA Kit - LS-F2366

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F24211

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

93.75 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F24219

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

93.75 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse/Human/Rat Phospho-NTRK2 / TRKB (Tyr515) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1061

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-NTRK2 / TRKB (Tyr705) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1062

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Chicken NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F46132

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F46133

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F46134

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F46136

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.938 - 60 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Human NTRK2 / TRKB (CLIA) ELISA Kit - LS-F30152

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F28723

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Mouse NTRK2 / TRKB (CLIA) ELISA Kit - LS-F30870

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F2716

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

93.8 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$795

Select

Human NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F25355

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

Select

Mouse NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F24045

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Pig NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F24268

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Pig

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat NTRK2 / TRKB (CLIA) ELISA Kit - LS-F37666

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Chicken NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F38950

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$755

Select

Rat NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F39006

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

Select

Human NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F39663

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates

Price:

1 Plate/$795

Select

Mouse NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F24907

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

93.8 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$717

Select

Mouse NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F32061

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F35421

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

93.75 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F35422

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

93.75 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat NTRK2 / TRKB (Sandwich ELISA) ELISA Kit - LS-F57058

Type:

Sandwich

Reactivity:

Rat

Range:

31.2 - 2000 pg/ml

Sample Types:

Cell Culture Supernatants, Cell Lysates

Price:

1 Plate/$795

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