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Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Gene Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
Synonyms: | NTMT1, AD-003, C9orf32, METTL11A, NTM1A, HOMT1A, NRMT, Methyltransferase like 11A |
Target Sequences: | NM_014064 NP_054783.2 Q9BV86 |
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