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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NTHL1

nth endonuclease III-like 1 (E. coli)

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Gene Name: nth endonuclease III-like 1 (E. coli)
Synonyms: NTHL1, OCTS3, NTH1
Target Sequences: NM_002528 NP_002519.1 P78549

Publications (4)

1
Zinc(II) inhibits the release of thyroid and glucocorticoid receptors from chromatin of cultured GC cells. Ramirez IJ, Halwer M, Shapiro LE, Surks MI. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et mtabolisme. 1991 23:155-61. (IHC; Mouse, Rat) [PubMed:1908429]
2
p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress. O'reilly MA, Vitiello PF, Gehen SC, Staversky RJ. Antioxidants & redox signaling. 7:719-25. [PubMed:15890018]
3
Altered expression of the human base excision repair gene NTH1 in gastric cancer. Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi T, Tsugane S, Sugimura H. Carcinogenesis. 2009 30:1345-52. [PubMed:19414504]
4
S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. Chang CL, Ho MC, Lee PH, Hsu CY, Huang WP, Lee H. American journal of physiology. Cell physiology. 2009 297:C451-8. [PubMed:19474291]
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Proteins (6)
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NTHL1 (6)
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GST (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
NTHL1 Protein - Purified recombinant protein NTHL1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$890
NTHL1 Protein - 12.5% SDS-PAGE of human NTHL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
60 kDa
2 µg/$385
NTHL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
100 µg/$375
NTHL1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$195
NTHL1 Protein
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E. coli
His
50 µg/$365; 250 µg/$935
NTHL1 Protein
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E. coli
His, N-Terminal
34.2 kDa
50 µg/$325
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).