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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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NTHL1

nth endonuclease III-like 1 (E. coli)

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Gene Name: nth endonuclease III-like 1 (E. coli)
Synonyms: NTHL1, OCTS3, NTH1
Target Sequences: NM_002528 NP_002519.1 P78549

Publications (4)

1
Zinc(II) inhibits the release of thyroid and glucocorticoid receptors from chromatin of cultured GC cells. Ramirez IJ, Halwer M, Shapiro LE, Surks MI. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et mtabolisme. 1991 23:155-61. (IHC; Mouse, Rat) [PubMed:1908429]
2
p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress. O'reilly MA, Vitiello PF, Gehen SC, Staversky RJ. Antioxidants & redox signaling. 7:719-25. [PubMed:15890018]
3
Altered expression of the human base excision repair gene NTH1 in gastric cancer. Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi T, Tsugane S, Sugimura H. Carcinogenesis. 2009 30:1345-52. [PubMed:19414504]
4
S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. Chang CL, Ho MC, Lee PH, Hsu CY, Huang WP, Lee H. American journal of physiology. Cell physiology. 2009 297:C451-8. [PubMed:19474291]
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Antibodies (36)
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NTHL1 (36)
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mouse (3)
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monoclonal mc (3)
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AP Conjugated (1)
APC Conjugated (1)
Biotin Conjugated (4)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (20)
aa88-117 (8)
aa91-140 (4)
aa150-200 (1)
No (36)
NTHL1 Antibody - Anti-NTH1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$425
NTHL1 Antibody - Anti-NTH1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTHL1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Biotin Conjugated
200 µl/$365
NTHL1 Antibody - Anti-NTH1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTHL1 Rabbit anti-Human Polyclonal (DY650) Antibody
Human
ICC, IHC, IHC-P, WB
DY650 Conjugated
200 µl/$365
NTHL1 Antibody - Anti-NTH1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTHL1 Rabbit anti-Human Polyclonal (DY488) Antibody
Human
ICC, IHC, IHC-P, WB
DY488 Conjugated
200 µl/$365
NTHL1 Antibody - Anti-NTH1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTHL1 Rabbit anti-Human Polyclonal (DY550) Antibody
Human
ICC, IHC, IHC-P, WB
DY550 Conjugated
200 µl/$365
NTHL1 Antibody - Western blot of A549 cells using NTH1 antibody. A band is seen at 35 kD representing NTH1.
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$335
NTHL1 Antibody - NTHL1 Antibody (Center R103) western blot of HeLa,NCI-H460 cell line lysates (35 ug/lane). The NTHL1 antibody detected the NTHL1 protein (arrow).
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) Antibody
Human
WB
Unconjugated
400 µl/$325
NTHL1 Antibody - Immunohistochemistry image of paraffin-embedded human glioma cancer at a dilution of 1:100
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$285; 100 µg/$385
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$355
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$725
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$590
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
200 µl/$740
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$740
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$740
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$740
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$740
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NTHL1 Rabbit anti-Human Polyclonal (aa88-117) (AP) Antibody
Human
ELISA, WB
AP Conjugated
200 µl/$740
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$335
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$305
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NTHL1 Mouse anti-Human Monoclonal (2660C1a) Antibody
Mouse, Rat, Human
DB, WB
Unconjugated
100 µg/$530
NTHL1 Antibody - Western blot analysis NTHL1 using RAW264.7 whole cells lysates
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$325; 200 µl/$375
NTHL1 Antibody - Detection of NTHL1 by Western blot. Samples: Whole cell lysate from human HEK293 (H, 25 ug) , mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. Predicted molecular weight: 34 kDa
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NTHL1 Mouse anti-Human Monoclonal (2660C1a) Antibody
Mouse, Rat, Human
DB, WB
Unconjugated
100 µg/$415
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NTHL1 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µg/$590
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$515
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NTHL1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$235; 120 µl/$295; 200 µl/$395
Viewing 1-25 of 36 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).