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NSUN2
NOP2/Sun RNA methyltransferase family, member 2
RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
| Gene Name: | NOP2/Sun RNA methyltransferase family, member 2 |
| Synonyms: | NSUN2, HTrm4, MISU, MRT5, SAKI, NOL1/NOP2/Sun domain family 2, TRM4 |
| Target Sequences: | NM_017755 NP_060225.4 Q08J23 |
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