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NSPC1 / PCGF1

polycomb group ring finger 1

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Name: polycomb group ring finger 1
Synonyms: PCGF1, Polycomb group ring finger 1, RNF3A-2, Nervous system Polycomb-1, NSPC1, RING finger protein 68, RNF68
Target Sequences: NM_032673 NP_116062.2 Q9BSM1

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
NSPC1 / PCGF1 (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
NSPC1 / PCGF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.2 kDa
100 µg/$494
NSPC1 / PCGF1 Protein - 12.5% SDS-PAGE of human PCGF1 stained with Coomassie Blue
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Wheat Germ Extract
GST
55.6 kDa
10 µg/$479; 25 µg/$670
NSPC1 / PCGF1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NSPC1 / PCGF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30.2 kDa
20 µg/$150
Viewing 1-4 of 4 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).