NRTN / Neurturin

neurturin

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRa. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. NTN binds to and forms a complex with GFRa-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

NRTN / Neurturin (5)

Publications

No (5)

Tag

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (3)

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NRTN / Neurturin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116563

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.41 kDa

Price:

100 µg/$494

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Human NRTN / Neurturin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77682

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.41 kDa

Price:

20 µg/$150

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Human NRTN / Neurturin Protein (Recombinant) - LS-G440

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

11.8 kDa

Price:

5 µg/$268; 20 µg/$349

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Human NRTN / Neurturin Protein (Recombinant) (Ala96-Val197) - LS-G139650

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.8 kDa

Price:

20 µg/$360; 100 µg/$728

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Human NRTN / Neurturin Protein (Recombinant) (Ala96-Val197) - LS-G51859

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.8kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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