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NRG1 / Heregulin / Neuregulin
neuregulin 1
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
| Gene Name: | neuregulin 1 |
| Synonyms: | NRG1, ARIA, GGF, GGF2, Glial growth factor, Heregulin, HRGA, MSTP131, NDF, Neu differentiation factor, Neuregulin 1 type IV beta 3, Neuregulin 1 type IV beta 1a, HRG1, NRG-1, SMDF, Neuregulin 1, Pro-NRG1, HGL, MST131 |
| Target Sequences: | NM_013964 NP_039258.1 Q02297 |
Publications (1)
1
Cell Lineage-Based Stratification for Glioblastoma. Zilai Wang, Daochun Sun, Yu-Jung Chen, Xuanhua Xie, Yufeng Shi, Viviane Tabar, Cameron W Brennan, Tejus A Bale, Chenura D Jayewickreme, Dan R Laks, Sheila Alcantara Llaguno, Luis F Parada. Cancer cell. 2020 Sep;38:366-379.e8. [Full Text Article]
[PubMed:32649888]
[PMC:PMC7494533]
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NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa198-229) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa617-636) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
E. coli
His-GST, N-terminus
45.3 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$281; 50 µg/$369
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
Human NRG1 / Heregulin / Neuregulin Protein (Recombinant 6His, N-terminus) (Met1-Lys246) - LS-G39858
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
Fast Shipping
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
NRG1 / Heregulin / Neuregulin Mouse anti-Human Monoclonal (aa20-242) (C3) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$492; 1 ml/$563; 2 ml/$758; 5 ml/$1,233
Fast Shipping
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$718
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (Tyr4) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa198-229) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa198-229) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa198-229) (APC) Antibody
Human
ELISA, Flo, IHC
APC Conjugated
200 µl/$952
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa198-229) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (aa198-229) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
NRG1 / Heregulin / Neuregulin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Microplate
Human
12.29 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
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