NR6A1 / GCNF

nuclear receptor subfamily 6, group A, member 1

Germ cell nuclear factor (GCNF), a NR6 Germ Cell Nuclear Factor-Like Receptor, has been shown to affect gene expression in embryogenesis and spermatogenesis and is essential for embryonic survival and normal development. Loss of GCNF causes embryonic lethality and disrupts normal somitogenesis as well as neural-tube and axis formation. GCNF binds as a homodimer to the DR0 DNA response element and has been shown to regulate transcription of genes including protamines1 and 2 and Oct4. GCNF's repression function has been shown to be mediated by interaction with the co-repressors N-COR and SMRT in the absence of ligand. Three protein isoforms, GCNF-1, GCNF-2a, and GCNF-2b, have been documented in humans, and they are generated by differential usage of alternative splice acceptor sites of the fourth and seventh exons. GCNF-1, the longest isoform, has a distinct 5' UTR and contains 4 and 26 additional amino acids than the other two forms, respectively.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

NR6A1 / GCNF (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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NR6A1 / GCNF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118551

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

100 µg/$494

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Human NR6A1 / GCNF Protein (Recombinant GST) (Full Length) - LS-G28598

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NR6A1 / GCNF Protein (Recombinant His-T7) (aa282-480) - LS-G24907

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.2 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human NR6A1 / GCNF Protein (Recombinant GST, N-terminus) (aa366-474) - LS-G58671

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR6A1 / GCNF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80049

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

20 µg/$150

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