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NR5A2 / LRH-1

nuclear receptor subfamily 5, group A, member 2

Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as 'human B1-binding factor' (HB1F), 'CYP7A promoter-binding factor' (CPF), and 'liver receptor homolog 1' (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis. Ftf has been shown to regulate aromatase activities in adipose tissue, and alterations in Ftf expression and/or activity in adipose tissue could have considerable effects on local estrogen production and breast cancer development. LRH has been shown to expressly strongly in gonadal tissues, and may play an important role in the regulation of gonadal function. Three isoforms of Ftf have been identified: wild type (495 aa), CPF variant 1 (contains a 46-aa insertion in the A/B domain), and CPF variant 2 (contains a 172-aa deletion within the D/E domain).

Gene Name: nuclear receptor subfamily 5, group A, member 2
Family/Subfamily: NHR , NR5 Fushi tarazu-like
Synonyms: NR5A2, B1F, B1F2, B1-binding factor, CPF, CYP7A promoter-binding factor, FTZ-F1beta, FTF, Liver receptor homolog 1, LRH1, LRH-1, HB1F, HB1F-2, Nuclear receptor phr-1, FTZ-F1, Liver receptor homolog-1, Nuclear receptor NR5A2, Receptor phr
Target Sequences: NM_003822 NP_003813.1 O00482

Publications (1)

1
Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:16927-31. (IHC-P; Human) [Full Text Article] [PubMed:21949357] [PMC:PMC3193228] Related Antibodies: LS-A2447.

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NR5A2 / LRH-1 ELISA Kit
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1 Plate/$929
NR5A2 / LRH-1 ELISA Kit
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1 Plate/$783
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1 Plate/$783
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0.313 - 20 ng/ml
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NR5A2 / LRH-1 ELISA Kit
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0.156 - 10 ng/ml
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).