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NR4A1 / NUR77

nuclear receptor subfamily 4, group A, member 1

Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.

Gene Name: nuclear receptor subfamily 4, group A, member 1
Family/Subfamily: NHR , NR4 Nerve growth factor-like
Synonyms: NR4A1, GFRP1, Early response protein NAK1, HMR, NGFIB, Orphan nuclear receptor TR3, Orphan receptor tr3, Steroid receptor TR3, TR3, NAK1, NGFI-B, NP10, Receptor NGFIB, Testicular receptor 3, TR3 orphan receptor, N10, NAK-1, NUR77, Orphan nuclear receptor HMR
Target Sequences: NM_002135 NP_002126.2 P22736

Publications (6)

1
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Circulation. 2009 119:577-86. (WB, IHC-P; Mouse) [Full Text Article] [PubMed:19153266] [PMC:PMC2748681]
2
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Cheng Z, Vlkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. European heart journal. 2011 32:2179-88. (ICC, IHC-P; Mouse, Rat) [Full Text Article] [PubMed:21228009] [PMC:PMC3164102]
3
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin gene: analysis of TRH knockout mice. Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M. PloS one. 2012 7:e40437. (ICC, WB, IHC-P, ChrIP; Mouse, Human, Rat) [Full Text Article] [PubMed:22792320] [PMC:PMC3392219]
4
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Wu H #, Bi J #, Peng Y #, Huo L #, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J,. Oncotarget. 2017 8:54364-54377. (ICC; Human) [Full Text Article] [PubMed:28903348] Related Antibodies: LS-B114.
5
Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease. Tabuchi Y, Kitamura T, Fukuhara A, Mukai K, Onodera T, Miyata Y, Hamasaki T, Oshino S, Saitoh Y, Morii E, Otsuki M, Shimomura I. Endocrine Journal. 2016 June;63:545-554. [Full Text Article] [PubMed:27025408] Related Antibodies: LS-B114.
6
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Kumaravel Mohankumar, Rupesh Shrestha, Stephen Safe. Molecular carcinogenesis. 2022 Janurary;61:73-84. [Full Text Article] [PubMed:34699643] [PMC:PMC8665050] Related Antibodies: LS-C118011.
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Proteins (4)
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NR4A1 / NUR77 (4)
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Wheat Germ Extract (3)
Purified (2)
NR4A1 / NUR77 Protein - Purified recombinant protein NR4A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
64.3 kDa
20 µg/$1,107
NR4A1 / NUR77 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NR4A1 / NUR77 Protein - 12.5% SDS-PAGE of human NR4A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
91.52 kDa
10 µg/$479; 25 µg/$670
NR4A1 / NUR77 Protein - 12.5% SDS-PAGE of human NR4A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
90.9 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).