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NR2E1 / TLX
nuclear receptor subfamily 2, group E, member 1
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.
| Gene Name: | nuclear receptor subfamily 2, group E, member 1 |
| Family/Subfamily: | NHR , NR2 Hepatocyte NF4-like |
| Synonyms: | NR2E1, HTll, Tailless homolog, Tailless, TLX, TLL, Nuclear receptor TLX, Protein tailless homolog, Tailes-related receptor, XTLL |
| Target Sequences: | NM_003269 NP_003260.1 Q9Y466 |
Publications (3)
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