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NR2E1 / TLX
nuclear receptor subfamily 2, group E, member 1
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.
| Gene Name: | nuclear receptor subfamily 2, group E, member 1 |
| Family/Subfamily: | NHR , NR2 Hepatocyte NF4-like |
| Synonyms: | NR2E1, HTll, Tailless homolog, Tailless, TLX, TLL, Nuclear receptor TLX, Protein tailless homolog, Tailes-related receptor, XTLL |
| Target Sequences: | NM_003269 NP_003260.1 Q9Y466 |
Publications (3)
1
Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment. Tejero R, Huang Y, Katsyv I, Kluge M, Lin JY, Tome-Garcia J, Daviaud N, Wang Y, Zhang B, Tsankova NM, Friedel CC, Zou H, Friedel RH. EBioMedicine. 2019 April;42:252-269. [Full Text Article]
[PubMed:30952620]
[PMC:PMC6491796]
Related Antibodies: LS-B4564.
2
The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. Daniel P Beiting, Shinya Hidano, Julie E Baggs, Jeanne M Geskes, Qun Fang, E John Wherry, Christopher A Hunter, David S Roos, Sara Cherry. PLoS biology. 2015 July;13:e1002200. [Full Text Article]
[PubMed:26196739]
[PMC:PMC4509904]
Related Antibodies: LS-B4564.
3
TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, P[Character e5]hlman S, Hansford L, Kaplan DR, Funa K. Cell death & disease. 5:e1502. (WB, IF, ChIP-Seq; Human)
[Full Text Article]
[PubMed:25356871]
[PMC:PMC4237266]
Related Antibodies: LS-B3505.
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NR2E1 / TLX Rabbit anti-Human Polyclonal (aa95-144) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa95-144) (HRP) Antibody
Chicken, Bovine, Pig, Horse, Bat, Rabbit, Dog, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa95-144) (Biotin) Antibody
Chicken, Bovine, Pig, Horse, Bat, Rabbit, Dog, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa95-144) (FITC) Antibody
Chicken, Bovine, Pig, Horse, Bat, Rabbit, Dog, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NR2E1 / TLX Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Insect, Drosophila, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Cancer
Fast Shipping
NR2E1 / TLX Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
NR2E1 / TLX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NR2E1 / TLX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
NR2E1 / TLX Mouse anti-Human Monoclonal (1C4) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$423
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa75-102) Antibody
Human
WB
Unconjugated
400 µl/$393
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa144-193) (HRP) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa144-193) (Biotin) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa144-193) (FITC) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR2E1 / TLX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR2E1 / TLX Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$680
NR2E1 / TLX Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NR2E1 / TLX Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa75-102) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa75-102) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
NR2E1 / TLX Rabbit anti-Human Polyclonal (aa75-102) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
NR2E1 / TLX Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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