NR2C2 / TAK1

nuclear receptor subfamily 2, group C, member 2

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

NR2C2 / TAK1 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NR2C2 / TAK1 Protein (Recombinant 6His, N-terminus) (aa3-592) - LS-G22688

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

68.9 kD

Price:

100 µg/$420; 20 µg/$323; 1 mg/$1,355

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Human NR2C2 / TAK1 Protein (Recombinant GST, N-terminus) (aa43-152) - LS-G60417

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR2C2 / TAK1 Protein (Recombinant GST) (Full Length) - LS-G30765

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.9 kDa

Price:

2 µg/$439

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Human NR2C2 / TAK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66495

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$1,107

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Human NR2C2 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77837

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$215

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NR2C2 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100021

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

100 µg/$710

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Human NR2C2 / TAK1 Protein (Recombinant His-T7, N-terminus) (Leu371-Leu596) - LS-G133418

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

29.3kDa

Price:

10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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