NR1I3 / CAR

nuclear receptor subfamily 1, group I, member 3

NR1I3 / CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

ELISA Kits (9)

Type

Cell-Based (1)

Custom (2)

DNA Binding (1)

Sandwich (5)

Target

NR1I3 / CAR (9)

Reactivity

Human (5)

Mouse (2)

Rat (2)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (7)

Publications

No (9)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (2)

Nuclear Lysates (1)

Plasma (4)

Serum (4)

Tissue Homogenates (4)

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Rat NR1I3 / CAR (Custom ELISA) ELISA Kit - LS-F19383

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human NR1I3 / CAR (Custom ELISA) ELISA Kit - LS-F19382

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human NR1I3 / CAR (Cell-Based ELISA) ELISA Kit - LS-F3195

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human NR1I3 / CAR (Sandwich ELISA) ELISA Kit - LS-F39009

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Human NR1I3 / CAR (Sandwich ELISA) ELISA Kit - LS-F33728

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse NR1I3 / CAR (Sandwich ELISA) ELISA Kit - LS-F33729

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat NR1I3 / CAR (Sandwich ELISA) ELISA Kit - LS-F33732

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human NR1I3 / CAR (DNA-Binding ELISA) ELISA Kit - LS-F814

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Mouse NR1I3 / CAR (Sandwich ELISA) ELISA Kit - LS-F12191

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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