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NR1I3 / CAR
nuclear receptor subfamily 1, group I, member 3
NR1I3 / CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | nuclear receptor subfamily 1, group I, member 3 |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | NR1I3, Car-beta, CAR1, Constitutive active receptor, Constitutive active response, Orphan nuclear receptor MB67, MB67, CAR |
| Target Sequences: | NM_005122 NP_005113.1 Q14994 |
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NR1I3 / CAR Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
NR1I3 / CAR Rabbit anti-Human Polyclonal (aa180-229) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NR1I3 / CAR Rabbit anti-Human Polyclonal (aa180-229) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR1I3 / CAR Rabbit anti-Human Polyclonal (aa180-229) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR1I3 / CAR Rabbit anti-Human Polyclonal (aa180-229) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR1I3 / CAR Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$397
NR1I3 / CAR Rabbit anti-Human Polyclonal (aa245-294) Antibody
Human
WB
Unconjugated
100 µl/$397
NR1I3 / CAR Rabbit anti-Mouse Polyclonal (aa121-170) Antibody
Mouse
WB
Unconjugated
100 µl/$397
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (OTI1C6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (Carrier-free) (OTI1C6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR1I3 / CAR Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
NR1I3 / CAR Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
0.1 mg/$379
NR1I3 / CAR Rabbit anti-Mouse Polyclonal (aa1-247) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
NR1I3 / CAR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR1I3 / CAR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (OTI10F9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (Carrier-free) (OTI10F9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR1I3 / CAR Rabbit anti-Human Polyclonal (40-120 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (Carrier-free) (OTI2H10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (OTI1B2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NR1I3 / CAR Mouse anti-Human Monoclonal (aa1-236) (Carrier-free) (OTI1B2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR1I3 / CAR Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
NR1I3 / CAR Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
NR1I3 / CAR Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
NR1I3 / CAR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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