NR1I2 / PXR

nuclear receptor subfamily 1, group I, member 2

Pregnane X receptor (PXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to mediate the effects of steroid hormones, including progesterone, glucocorticoid, and pregnenolone, and effects of xenobiotics, through the cytochrome P-450 3A gene family (CYP3A). PXR protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. PXR also has been suggested to regulate drug efflux by activating expression of the MDR1 gene, control the biosynthesis and metabolism of bile acids, and influence the protection of the feto-maternal system from the toxic effects of endogenous steroids and foreign substrates. PXR binds as a heterodimer (with RXR) to the CYP3A promoter region. At least six protein isoforms, produced by alternative splicing, have been reported.

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Products

ELISA Kits (15)

Type

Sandwich (14)

Sandwich CLIA (1)

Target

NR1I2 / PXR (15)

Reactivity

Human (5)

Mouse (2)

Rat (2)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (13)

Publications

No (14)

Yes (1)

Sample Type

Cell Lysates (2)

Plasma (7)

Serum (7)

Tissue Homogenates (4)

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Human NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F12190

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F15858

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F6765

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Chicken NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F47025

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F47026

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F47027

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F47028

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F47029

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F47030

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Human NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F21266

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F12189

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Mouse NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F34155

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F34157

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NR1I2 / PXR (CLIA) ELISA Kit - LS-F30370

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat NR1I2 / PXR (Sandwich ELISA) ELISA Kit - LS-F7615

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

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