NR1H2 / LXR Beta

nuclear receptor subfamily 1, group H, member 2

Liver X receptor beta (LXR beta), a NR1 thyroid hormone-like receptor, has been shown to affect cholesterol and bile acid metabolism, as well as fatty acid metabolism. LXR beta mediates gene products controlling intracellular cholesterol homeostasis through the interaction with oxysterols including 22(R)-hydroxycholesterol, 24(S)-hydroxycholesterol, and 24(S),25-epoxycholesterol. LXR beta binds as a heterodimer to target sequences with retinoid X receptors and has been shown to activate a diverse set of genes involved in cholesterol and fatty acid metabolism, including ABCA1, ABCG5, ABCG8, SREBP-1c, fatty acid synthase (FAS), and the apoE/C-I/C-IV/C-II gene cluster upon ligand activation. Recently both LXR alpha and LXR beta have been shown to be important factors in atherosclerosis (Tangirala et al. 2002)

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

NR1H2 / LXR Beta (5)

Publications

No (5)

Tag

GST (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Mouse NR1H2 / LXR Beta Protein (Recombinant His-T7, N-terminus) (Met1-Glu446) - LS-G133492

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

53.4kDa

Price:

10 µg/$277; 50 µg/$417; 200 µg/$832; 100 µg/$667; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Human NR1H2 / LXR Beta Protein (Recombinant GST) (Full Length) - LS-G30846

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.45 kDa

Price:

2 µg/$439

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Human NR1H2 / LXR Beta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66455

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.9 kDa

Price:

20 µg/$1,107

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Human NR1H2 / LXR Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77756

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.9 kDa

Price:

20 µg/$150

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NR1H2 / LXR Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100977

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.9 kDa

Price:

100 µg/$494

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