NR1A2 / THRB

thyroid hormone receptor, beta

Thyroid hormone receptor beta (TR beta), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cholesterol metabolism, hearing, cone development in the eye, and hypothalamopituitary-thyroid axis function. Mice lacking the TR beta locus exhibit elevated thyroid hormone levels, profound hearing loss, impaired weight gain, abnormal bone development, and loss of thyroid-hormone induced activation of cholesterol 7 alpha-hydroxylase (CYP7A). Mutation in the ligand-binding domain of TR beta has been linked to the genetic disorder Resistance to Thyroid Hormone (RTH), and possibly to human cone disorders. Congenital thyroid disorders that impair hearing and result in profound deafness are common in geographic areas with a prevalence of iodine deficiency. Two human TR beta protein isoforms have been identified: TR beta1 (461 aa), TR beta2 (476 aa). Two additional protein isoforms, TR beta3 (390 aa), and a non-DNA binding TR deltabeta3 (288 aa), have been documented in rat.

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Products

Proteins (11)

Type

Over-Expression Lysate (6)

Recombinant (5)

Target

NR1A2 / THRB (11)

Publications

No (11)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Species

Human (8)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (4)

Wheat Germ Extract (1)

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NR1A2 / THRB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124763

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

100 µg/$494

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NR1A2 / THRB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124762

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

100 µg/$494

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Human NR1A2 / THRB Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60351

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR1A2 / THRB Protein (Recombinant His, N-Terminal) - LS-G144964

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

52.6 kDa

Price:

50 µg/$419

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Human NR1A2 / THRB Protein (Recombinant His-SUMO) (Full Length) - LS-G21257

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

68.75 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human NR1A2 / THRB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67121

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

20 µg/$1,107

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Human NR1A2 / THRB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79168

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

20 µg/$215

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Human NR1A2 / THRB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79170

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

20 µg/$150

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Human NR1A2 / THRB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79169

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

20 µg/$150

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NR1A2 / THRB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99048

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.6 kDa

Price:

100 µg/$710

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Human NR1A2 / THRB Protein (Recombinant His-T7) (aa239-457) - LS-G13022

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.6 kDa

Price:

50 µg/$402; 10 µg/$275; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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