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NPRB / NPR2 is natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
Gene Name: | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) |
Family/Subfamily: | Protein Kinase , Receptor guanylate cyclase |
Synonyms: | NPR2, ANPRB, AMDM, ANP-B, ANPR-B, ANPb, Guanylate cyclase B, GUCY2B, GC-B, GUC2B, Natriuretic peptide receptor B, NPR-B, NPRB, Natriuretic peptide receptor 2, NPRBi |
Target Sequences: | NM_003995 NP_003986.2 P20594 |
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