NPRA / NPR1

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NPRA / NPR1 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

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Human NPRA / NPR1 Protein (Recombinant His) (aa33-473) - LS-G23061

Source:

Yeast

Tag:

His

Molecular Weight:

50.9 kD

Price:

500 µg/$1,052; 100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human NPRA / NPR1 Protein (Recombinant His-SUMO) (aa33-473) - LS-G21014

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

64.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human NPRA / NPR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65026

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.7 kDa

Price:

20 µg/$1,107

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NPRA / NPR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122932

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.7 kDa

Price:

100 µg/$494

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Human NPRA / NPR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74670

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.7 kDa

Price:

20 µg/$150

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Human NPRA / NPR1 Protein (Recombinant GST, N-terminus) (aa147-247) - LS-G59435

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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