NPR2L / TUSC4

nitrogen permease regulator-like 2 (S. cerevisiae)

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

NPR2L / TUSC4 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human NPR2L / TUSC4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80574

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$150

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Human NPR2L / TUSC4 Protein (Recombinant GST) (Full Length) - LS-G32274

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.54 kDa

Price:

10 µg/$479; 25 µg/$670

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NPR2L / TUSC4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115240

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

100 µg/$494

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