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NPPA / ANP

Natriuretic Peptide A

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Gene Name:	Natriuretic Peptide A
Synonyms:	NPPA, ANF, ANP, Atriopeptin, ATFB6, Atrial natriuretic factor, CDD-ANF, Cardionatrin, Natriuretic peptides A, Prepronatriodilatin, Natriuretic peptide A, PND, Natriuretic peptide precursor A
Target Sequences:	NM_006172 NP_006163.1 P01160

Publications (3)

Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation. Imre J Pavo, Noemi Pavo, Nina Kastner, Denise Traxler, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Martin Riesenhuber, David Lorant, Philipp E Bartko, Georg Goliasch, Martin Hülsmann, Johannes Winkler, Mariann Gyöngyösi. JACC. Basic to translational science. 2020 July;5:715-726. [Full Text Article] [PubMed:32760858] [PMC:PMC7393434]

Synergy between sacubitril and valsartan leads to hemodynamic, antifibrotic, and exercise tolerance benefits in rats with preexisting heart failure. Mikhail Y Maslov, Stephan Foianini, Dita Mayer, Michael V Orlov, Mark A Lovich. American journal of physiology. Heart and circulatory physiology. 2019 Feb;316:H289-H297. [Full Text Article] [PubMed:30461302]

Full Issue PDF. No authors listed. JACC. Basic to translational science. 2020 July;5:I-CX. [Full Text Article] [PubMed:32835137] [PMC:PMC7384789]

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