NPM1 / NPM / Nucleophosmin

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.

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Products

Proteins (17)

Type

Over-Expression Lysate (6)

Recombinant (11)

Target

NPM1 / NPM / Nucleophosmin (17)

Publications

No (17)

Tag

6His-SUMO, N-terminus (1)

GST (1)

His (5)

His,N-terminus (1)

Myc-DDK (Flag) (9)

Species

Human (11)

Mouse (3)

Source

293T Cells (3)

E. coli (7)

HEK 293 Cells (6)

Wheat Germ Extract (1)

Purification

Purified (4)

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant His) - LS-G1798

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant His,N-terminus) (Met9-Leu158) - LS-G138116

Source:

E. coli

Tag:

His,N-terminus

Molecular Weight:

17.8 kDa

Price:

100 µg/$721

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NPM1 / NPM / Nucleophosmin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117936

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

100 µg/$494

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NPM1 / NPM / Nucleophosmin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120539

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

100 µg/$494

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant GST) (Full Length) - LS-G29536

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

58.08 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse NPM1 / NPM / Nucleophosmin Protein (Recombinant 6His-SUMO, N-terminus) (aa1-292) - LS-G56779

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67844

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

20 µg/$1,107

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67845

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.3 kDa

Price:

20 µg/$1,107

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67846

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

20 µg/$1,107

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Human NPM1 / NPM / Nucleophosmin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80835

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.3 kDa

Price:

20 µg/$150

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Human NPM1 / NPM / Nucleophosmin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80833

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

20 µg/$150

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Human NPM1 / NPM / Nucleophosmin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80834

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

20 µg/$150

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NPM1 / NPM / Nucleophosmin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103450

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.3 kDa

Price:

100 µg/$494

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant His) (aa20-154) - LS-G15026

Source:

E. coli

Tag:

His

Molecular Weight:

16.0 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human NPM1 / NPM / Nucleophosmin Protein (Recombinant His) (aa204-290) - LS-G15025

Source:

E. coli

Tag:

His

Molecular Weight:

11.3 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse NPM1 / NPM / Nucleophosmin Protein (Recombinant His) (aa212-292) - LS-G15029

Source:

E. coli

Tag:

His

Molecular Weight:

10.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Mouse NPM1 / NPM / Nucleophosmin Protein (Recombinant His) (aa20-154) - LS-G15030

Source:

E. coli

Tag:

His

Molecular Weight:

16.0 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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