NPM1 / NPM / Nucleophosmin

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.

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Products

ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Sandwich (1)

Target

NPM1 / NPM / Nucleophosmin (4)

Reactivity

Human (4)

Mouse (3)

Rat (3)

Format

96-Well Microplate (3)

96-Well Strip Plate (1)

Publications

No (4)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (1)

Tissue Homogenates (1)

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Human NPM1 / NPM / Nucleophosmin (Sandwich ELISA) ELISA Kit - LS-F6787

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Mouse/Human/Rat NPM1 / NPM / Nucleophosmin (Cell-Based ELISA) ELISA Kit - LS-F2191

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human/Rat Phospho-NPM1 / NPM / Nucleophosmin (Thr234) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1423

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-NPM1 / NPM / Nucleophosmin (Thr199) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1265

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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