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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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NPL / C112
N-acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase)
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
| Gene Name: | N-acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase) |
| Synonyms: | NPL, C1orf13, Sialic acid lyase, Sialate-pyruvate lyase, N-acetylneuraminate lyase, NAL, Sialate lyase, Sialic acid aldolase, C112, DHDPS1, NALase, NPL1 |
| Target Sequences: | NM_030769 NP_110396.1 Q9BXD5 |
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