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NPHS1 / Nephrin

nephrosis 1, congenital, Finnish type (nephrin)

NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Gene Name: nephrosis 1, congenital, Finnish type (nephrin)
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: NPHS1, Nephrin, NPHN, CNF
Target Sequences: NM_004646 NP_004637.1 O60500

Publications (5)

1
Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis. O'Sullivan KM, Ford SL, Longano A, Kitching AR, Holdsworth SR. American journal of physiology. Renal physiology. 2018 November;315:F1283-F1294. [Full Text Article] [PubMed:29923769] [PMC:PMC6293285]
2
Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice. Kentaro Terai, Denan Jin, Kenji Watase, Akihisa Imagawa, Shinji Takai. International journal of molecular sciences. 2020 October;21: [Full Text Article] [PubMed:33050674] [PMC:PMC7589797] Related Antibodies: LS-B1382.
3
Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats. K Salaga-Zaleska, P Pikul, E Kreft, S Herman, G Chyla, K Dabkowski, A Kuchta, M Lenartowicz, M Jankowski. Biomedicine & pharmacotherapy = Biomdecine & pharmacothrapie. 2021 July;139:111683. [Full Text Article] [PubMed:34243631]
4
Urinary Nephrin as a Biomarker of Glomerular Maturation and Injury Is Associated with Acute Kidney Injury and Mortality in Critically Ill Neonates. Jiao Chen, Gen Li, Sanfeng Wang, Xiaohan Hu, Yunqing Sun, Xiaomei Dai, Zhenjiang Bai, Jian Pan, Xiaozhong Li, Jian Wang, Yanhong Li. Neonatology. 2019 April;116:58-66. [Full Text Article] [PubMed:30982033]
5
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. Nature communications. 2019 August;10:3656. [Full Text Article] [PubMed:31409793] [PMC:PMC6692336] Related Antibodies: LS-C370063.
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NPHS1 / Nephrin Antibody - Anti-Nephrin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
NPHS1 / Nephrin Antibody - Anti-Nephrin antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal (aa1218-1234) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
NPHS1 / Nephrin Antibody - Immunofluorescence of cultured mouse podocyte cells for nephrin
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NPHS1 / Nephrin Guinea pig anti-Human Polyclonal (aa1243-1256) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$959
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NPHS1 / Nephrin Guinea pig anti-Human Polyclonal (aa1243-1256) Antibody
Human
IF, IHC
Unconjugated
100 µl/$952
NPHS1 / Nephrin Antibody - Immunohistochemistry of paraffin-embedded mouse kidney tissue.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NPHS1 / Nephrin Protein - Recombinant Nephrin By SDS-PAGE
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E. coli
His
12.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
NPHS1 / Nephrin Protein - Recombinant Nephrin By SDS-PAGE
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E. coli
His-GST
38.4 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$771
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
1 Plate/$764
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates, Urine
1 Plate/$818
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
1 Plate/$782
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NPHS1 / Nephrin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50 µl/$324; 100 µl/$400
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NPHS1 / Nephrin Mouse anti-Human Monoclonal (3H6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
NPHS1 / Nephrin Antibody
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NPHS1 / Nephrin Mouse anti-Rat Monoclonal Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
NPHS1 / Nephrin Antibody - Western blot of recombinant NPHS1 / Nephrin.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal (aa27-234) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$307; 200 µl/$349; 500 µl/$487; 1 ml/$556; 2 ml/$745; 5 ml/$1,209
NPHS1 / Nephrin Antibody - 1:100 staining human kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NPHS1 / Nephrin Protein - Recombinant Nephrin By SDS-PAGE
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E. coli
His, N-Terminal
26.7 kDa
10 µg/$271; 50 µg/$377; 100 µg/$602; 200 µg/$752; 1 mg/$1,804; 500 µg/$1,367; 5 mg/$2,762; 2 mg/$1,985
NPHS1 / Nephrin Protein - Recombinant Nephrin By SDS-PAGE
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E. coli
His, N-Terminal
41.7 kDa
10 µg/$271; 50 µg/$377; 100 µg/$602; 200 µg/$752; 1 mg/$1,804; 500 µg/$1,367; 5 mg/$2,762; 2 mg/$1,985
NPHS1 / Nephrin Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal (aa23-257) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
NPHS1 / Nephrin Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal (aa23-257) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
NPHS1 / Nephrin Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal (aa23-257) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
NPHS1 / Nephrin Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NPHS1 / Nephrin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
Viewing 1-25 of 130 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).