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NPFF2 / NPFFR2

neuropeptide FF receptor 2

The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. The receptor is expressed in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, and in adipose tissue, suggesting other physiological and pathophysiological activities for FMRF-amide neuropeptides (Elshourbagy et al, 2000). Four isoforms are produced by alternative splicing.

Gene Name:	neuropeptide FF receptor 2
Family/Subfamily:	GPCR , Neuropeptide
Synonyms:	NPFFR2, G protein-coupled receptor 74, HLWAR77, G-protein coupled receptor 74, Neuropeptide FF receptor 2, Neuropeptide FF 2, NPFF2, Neuropeptide FF 2 receptor, NPGPR, GPR74, NPFF-R2, NPFF2 receptor, NPGP receptor
Target Sequences:	NM_004885 NP_004876.2 Q9Y5X5

Publications (2)

Neuropeptide FF activates ERK and NF kappa B signal pathways in differentiated SH-SY5Y cells. Sun YL, Zhang XY, He N, Sun T, Zhuang Y, Fang Q, Wang KR, Wang R. Peptides. 2012 38:110-7. (ICC, WB; Human) [PubMed:22981806]

Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium. Narita K, Kawate T, Kakinuma N, Takeda S. Traffic (Copenhagen, Denmark). 2010 Feb;11:287-301. [Full Text Article] [PubMed:19958467] Related Antibodies: LS-A463.

Human NPFF2 / NPFFR2 Protein (Recombinant His) (Full Length) - LS-G23059

Source:

Yeast

Tag:

His

Molecular Weight:

50.7 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Products: Proteins

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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